Best friends Mikan and Hotaru grew up in a small town in the remote countryside. When Hotaru moves to a school for geniuses in Tokyo, Mikan misses Hotaru so badly that she decides to travel to Tokyo herself to find Hotaru. She finds Hotaru in a school called "Alice Academy," and finds that the school is actually for people with special powers called "Alices." Narumi-sensei, a teacher at the school, discovers that Mikan also happens to have an Alice, and Mikan is admitted into the academy. There she finds friends, love, and a life that she will never forget.
[edit] Differences between manga and anime
The anime episodes are similar to the corresponding manga chapters, but some events are changed or combined. The manga's darker tones are reduced in the anime to suit younger viewers. A number of episodes of the anime were not based on the manga at all. Characters in the anime may have different hair and eye color than their manga counterparts. The anime series leaves the love triangle between Mikan, Ruka, and Natsume unresolved, with Mikan having not realized their feelings for her, and the mystery of Mikan's parents remains unrevealed. Neither does she get stuck to Natsume with the 'Sticky Balls'. In the first episode, she doesn't catch a taxi to Gakuen Alice, nor does everyone know about Alices in the anime. Many of these differences may be due to the fact that the anime has had only one season, while the manga is ongoing.