Deep Blue Seais a 1999 science fiction horror film that stars Thomas Jane , Saffron Burrows , LL Cool J , and Samuel L Jackson . The film was directed by Renny Harlin and was released in the United States on July 28, 1999.

On Aquatica, a remote former submarine refueling facility, a team of scientists are searching for a cure for Alzheimer's disease . Dr. Susan McAlester ( Saffron Burrows ), violates a code of ethics (the fictitious "Harvard Genetics Compact"), and genetically engineers three Mako sharks to increase their brain capacity so their brain tissue can be harvested as a cure for Alzheimer's. The increased brain capacity makes the sharks smarter, faster, and more dangerous. Aquatica's financial backers become skeptical about the tests and send a corporate executive ( Samuel L. Jackson ) to visit the facility.

To prove that the research is working, the team manage to remove brain tissue from the largest shark. The shark attacks a scientist, and as he is put into a helicopter to be flown to land, the helicopter crashes. A shark breaks the glass of the underwater laboratory, flooding it and letting the sharks inside the facility. The group has to escape the sinking research center and avoid being killed; the sharks are targeting the scientists as prey.

The team is slowly killed off by the sharks as they climb to the top of the facility. The cook, Preacher ( LL Cool J ); the shark wrangler, Carter Blake ( Thomas Jane ); and Dr. McAlester are the only ones to ascend to the top of the building. They discover that the sharks want to escape into the open sea.

Dr. McAlester, in a effort to distract the last of the three sharks,cuts herself and dives into the water, while she attempts to get back to land the ladder crumbles and breaks, she is then killed by the shark . Her death lures the shark into a position where Preacher and Blake can kill it. Preacher and Blake wait on top of the flooded facility as they see boats containing other researchers arriving.